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Moreover, elevated homocysteine levels have been associated with enhanced in vivo lipid and protein oxidation in humans, as suggested by the correlation obtained between plasma homocysteine and F 2 -isoprostanes, relevant biomarkers of nonenzymatic peroxidation (Ventura et al, 2000

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In summary, periodontitis-associated oral microbiota may contribute to the pathogenesis and progression of depression by modulating gut microbiota composition and engaging immune-inflammatory pathways involving Th17 cell differentiation and microglia-mediated neuroinflammation